List of Projects
 
  • Wnt proteins as triggers for osteophyte formation
    This project will aim to characterize the molecular mechanisms of osteophyte formation in osteoarthritis and inflammatory arthritis and focuses on the role of Wnt proteins and their inhibitors, which are key factors for bone homeostasis.
  • Apolipoproteins and osteophyte formation
    This subproject is dedicated to link apolipoprotein E (apoE), a key component of the lipoprotein metabolism to osteophyte formation. ApoE is an inhibitor of Wnt proteins and negatively regulates inflammatory responses
  • The role of adipokines in osteophyte formation
    This subproject will investigate the role adipokines, a novel cytokine family stemming from the adipose tissue in osteoarthritis. Fat-derived adipokines modulate inflammatory responses and may also modulate bone homeostasis, in particular osteophyte formation.
  • Biomarkers of osteophyte formation
    This subproject will be focused on biomarkers of osteophyte formation and will use well-defined clinical cohorts such as the German Spondyloarthritis Inception Cohort (GESPIC) (AS), the Bruneck cohort (OA) and a cohort of PsA patients to search for serum biomarker of osteophyte formation.
  • Genetic factors in osteophyte formation
    This subproject will attempt to link the susceptibility to osteophyte formation to specific genetic variants based on genome wide association study (GWAS) performed in PsA patients and then translate these findings into other diseases such as ankylosing spondylitis and osteoarthritis.
  • Imaging of osteophytes
    This subproject aims to improve imaging technology in depicting osteophytes and joint ankylosis by defining the morphology, size and the exact predilection sites of osteophytes by techniques such as high-resolution computed tomography imaging.
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