Publications


  • Töpfer D, Finzel S, Museyko O, Schett G, Engelke K. Segmentation and quantification of bone erosions in high-resolution peripheral quantitative computed tomography datasets of the metacarpophalangeal joints of patients with rheumatoid arthritis. Rheumatology (Oxford). 2014 Jan;53(1):65-71.
     
  • Araujo E., Finzel S., Englbrecht M., Schreiber D., Faustini F., Hueber A., Nas K., Rech J., Schett G.. High incidence of disease recurrence after discontinuation of disease-modifying antirheumatic drug treatment in patients with psoriatic arthritis in remission. Ann Rheum Dis. 2013 Dec 12.
     
  • Kocijan R, Finzel S, Englbrecht M, Engelke K, Rech J, Schett G. Decreased quantity and quality of the periarticular and non-periarticular bone in patients with rheumatoid arthritis: A cross-sectional HR-pQCT study. J Bone Miner Res. 2013 Oct 5.
     
  • Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013 Oct;72(10):1732-6.
     
  • Albrecht A, Finzel S, Englbrecht M, Rech J, Hueber A, Schlechtweg P, Uder M, Schett G. The structural basis of MRI bone erosions: an assessment by microCT. Ann Rheum Dis. 2013 Aug;72(8):1351-7.
     
  • Finzel S, Kraus S, Schmidt S, Hueber A, Rech J, Engelke K, Englbrecht M, Schett G. Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors. Ann Rheum Dis. 2013 Jul;72(7):1176-81.
     
  • Aschenberg S, Finzel S, Schmidt S, Kraus S, Engelke K, Englbrecht M, Rech J, Schett G. Catabolic and anabolic periarticular bone changes in patients with rheumatoid arthritis: a computed tomography study on the role of age, disease duration and bone markers. Arthritis Res Ther. 2013 May 27;15(3):R62.
     
  • Scholtysek C, Fu H, Katzenbeisser J, Uderhardt S, Stock M, Donhauser L, Zaiss MM, Böhm C, Kleyer A, David JP, Desvergne B, Schett G, Kronke. PPARß governs Wnt-signaling and bone turnover.Nat Med. 2013 May;19(5):608-13.
     
  • Ruiz-Heiland G, Zhao Y, Derer A, Braun T, Engelke K, Neumann E, Mueller-Ladner U, Liu Y, Zwerina J, Schett G. Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis. Ann Rheum Dis. 2013 Apr 30.
     
  • Herz B, Albrecht A, Englbrecht M, Welsch GH, Uder M, Renner N, Schlechtweg P, Paul D, Lauer L, Engelke K, Janka R, Rech J, Schett G, Finzel S. Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis. Ann Rheum Dis. 2013 Apr 26.
     
  • Braun T, Lepper J, Heiland GR, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler JH, Schett G, Zwerina J. Mitogen- activated protein kinase 2 (MK2) regulates physiological and pathological bone turnover. J Bone Miner Res. 2013 Apr;28(4):936-47.
     
  • Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, Schett G. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2013 Mar 21.  [Epub ahead of print]
     
  • Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, Bonora E, Tilg H, Willeit J, Schett G. Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013 Mar;19(3):358-63.
     
  • Finzel S, Rech J, Schmidt S, Engelke K, Englbrecht M, Schett G.. Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study. Ann Rheum Dis. 2013 Mar;72(3):396-400.
     
  • Schett G, Kleyer A, Perricone C, Sahinbegovic E, Iagnocco AM, Zwerina J, Lorenzini R, Aschenbrenner F, Berenbaum F, D'Agostino MA, Willeit J, Kiechl S. Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study. Diabetes care. 2013 Feb;36(2):403-9.
     
  • Husar-Memmer E, Ekici A, Al Kaissi A, Sticht H, Manger B, Schett G, Zwerina J. Premature Osteoarthritis as Presenting Sign of Type II Collagenopathy: A Case Report and Literature Review. Semin Arthritis Rheum. 2013 Feb;42(4):355-60.
     
  • Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann J, Schett G, Krönke G. LXRs orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res. 2012 Dec;27(12):2442-51.
     
  • Harre U, Keppeler H, Ipseiz N, Derer A, Poller K, Aigner M, Schett G, Herrmann M, Lauber K. Moonlighting osteoclasts as undertakers of apoptotic cells. Autoimmunity. 2012 Dec;45(8):612-9.
     
  • Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nature reviews Rheumatology. 2012 Nov;8(11):656-64.
     
  • Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P, Schett G.. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012 Apr 16. pii: 60975. 
     
  • RaunerM, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G, Distler JH, Albers J, Schulze J, Schinke T, Bornhäuser M, Platzbecker U, Hofbauer LC.. WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. J Bone Miner Res. 2012 Mar;27(3):575-85.
     
  • Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, Macdougald OA, Distler O, Schett G, Distler JH. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.Nat Commun. 2012 Mar 13;3:735.
     
  • Ruiz-Heiland G, Horn A, Zerr P, Hofstetter W, Baum W, Stock M, Distler JH, Nimmerjahn F, Schett G, Zwerina J.. Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. Ann Rheum Dis. 2012 Jan 10.
     
  • Heiland GR, Appel H, Poddubnyy D, Zwerina J, Hueber A, Haibel H, Baraliakos X, Listing J, Rudwaleit M, Schett G, Sieper J.. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis. 2011.
     
  • Bay-Jensen AC, Leeming DJ, Kleyer A, Veidal SS, Schett G, Karsdal MA.. Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study. Rheumatol Int. 2011 Nov 16.
     
  • Docampo E, Giardina E, Riveira-Muñoz E, de Cid R, Escaramís G, Perricone C, Fernández-Sueiro JL, Maymó J, González-Gay MA, Blanco FJ, Hüffmeier U, Lisbona MP, Martín J, Carracedo A, Reis A, Rabionet R, Novelli G, Estivill X. Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: a study in Spanish and Italian populations and meta-analysis.Arthritis Rheum. 2011 Jul;63(7):1860-5. doi: 10.1002/art.30340.
     
  • Schett G. Structural bone changes in spondyloarthritis: mechanisms, clinical impact and therapeutic considerations. Am J Med Sci. 2011 Apr;341(4):269-71.
     
  • Poddubnyy D, Haibel H, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J, Rudwaleit M. Baseline radiographic damage, elevated acute phase reactants and cigarette smoking status predict radiographic progression in the spine in early axial spondyloarthritis. Arthritis Rheum. 2011 Nov 29. doi: 10.1002/art.33465.
     
  • Zwerina K, Baum W, Axmann R, Ruiz Heiland G, Distler JH, Smolen J, Hayer S, Zwerina J, Schett G.
    Vitamin D receptor regulates TNF-mediated arthritis. Ann Rheum Dis. 2011 Mar 17.

     
  • Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M, Kollias G, Straub RH, Sporns O, Doerfler A, Brune K, Schett G.
    Blockade of TNF-? rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3731-6. Epub 2011 Jan 18.

     
  • Finzel S, Englbrecht M, Engelke K, Stach C, Schett G.
    A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis. Ann Rheum Dis. 2010 Oct 11.

     
  • Zaiss MM, Sarter K, Hess A, Engelke K, Böhm C, Nimmerjahn F, Voll R, Schett G, David JP.
    Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum. 2010 Aug;62(8):2328-38.

     
  • Sahinbegovic E, Dallos T, Aigner E, Axmann R, Engelbrecht M, Schöniger-Hekele M, Karonitsch T, Farkas M, Karger T, Willeit J, Stölzel U, Keysser G, Datz C, Kiechl S, Schett, G., Zwerina J.
    Hereditary hemochromatosis as a risk factor for joint replacement surgery. Am J Med. 2010 Jul;123(7):659-62.

     
  • Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hünig T, Schett G, David JP.
    Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis. J Immunol. 2010 June 15.

     
  • Schett G, Rudwaleit M.
    Can we stop progression of ankylosing spondylitis? Best Pract Res Clin Rheumatol. 2010 Jun;24(3):363-71.